The aging in our arteries can now be delayed by a fast triggering molecule derived by a new research conducted. Cancer, cardiovascular disease and Alzheimer’s can now be prevented by this anti-aging molecule.
Signs of aging like hair loss and wrinkles were first stopped in mice by researchers in a recent study. The interesting part is that with the concept, aging human cells can now be rejuvenated as proven by another team of researchers in the same study.
Fasting and or restricting one’s calorie intake can produce a molecule that delays vascular aging according to a team of scientists led by Dr. Ming-Hui Zou, the director of the Center for Molecular and Translational Medicine as Georgia State University in Atlanta. From this study, more and more evidence is shown that the aging process can in fact be reversed.
Dr. Zou explains the motivation for this study, saying, “The most important part of aging is vascular aging. When people become older, the vessels that supply different organs are the most sensitive and more subject to aging damage, so studying vascular aging is very important.”
With the aim on ways to prevent vascular aging, the scientists set out and studied vascular aging diligently, noting the changes that occur.
The link between calorie restriction and vascular aging were observed by the researchers.
Dr. Zou studied the aortas of the mouse models of atherosclerosis post-mortem, and a series of cell culture experiments is performed.
Starvation in rodents along with other similar tests were also induced.
The beta-hydroxybutyrate molecule was produced from the starving mice as they expected though the part that surprised the scientists is the anti-aging vascular molecule.
Ketone is the beta-hydroxybutyrate molecule that is used as an energy source when glucose is not available and is produced by the liver. Fasting or starvation on low-carb diets and after continuous exercise makes the body produce ketones
The beta-hydroxybutyrate promotes the multiplication as well as division of the cells that line the inside of blood vessels according to the research results. What they found was that the marker of cellular youth was from cellular division.
“This compound can delay vascular aging through endothelial cells,” said Dr. Zou
Dr. Zou explains, “which line the interior surface of blood vessels and lymphatic vessels. It can prevent one type of cell aging called senescence, or cellular aging.”
The compound triggers a chain reaction that keeps the DNA of the endothelial cells youthful and undamaged, another feature revealed in the results of the study.
Octamer-binding transcriptional factor (Oct4) is the activity of stem cell transcriptional factor which happens when beta-hydroxybutyrate attaches the RNA-binding protein heterogeneous nuclear ribonucleoprotein A1.
So in conclusion, Oct4 “increases Lamin B1, a key factor against DNA damage-induced senescence,” which keeps the blood vessels youthful and effecient.
“This stem cell factor (Oct4),” says Dr. Zou, “could be a pharmaceutical or pharmacological target for slowing down or preventing aging.”
10th April 2020 23:30
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